Selected Publications:

Smyth, AM, Rickman, C, Duncan, RR “Vesicle fusion probability is determined by the specific interactions of Munc18” J Biol Chem 285: 38141-41 (2010)

Rickman, C, Medine, CN, Dun, AR, Moulton, DJ, Mandula, O, Halemani, ND, Rizzoli, SO, Chamberlain, LH, Duncan, RR “t-SNARE protein conformations patterned by the lipid microenvironment” J Biol Chem 285: 13535-41 (2010)

Smyth, AM, Duncan, RR, Rickman, C “Munc18-1 and Syntaxin1: unravelling interactions between the dynamic duo” Cell and Molecular Neurobiology 30: 1309-13 (2010)

Rickman, C and Duncan, RR “Munc18/ Syntaxin interaction kinetics control secretory vesicle dynamics” J Biol Chem 285: 3965-72 (2010)

Soriano, FX, Martel, MA, Papadia S, Vaslin, A, Baxter, P, Rickman, C, Forder J, Tymianski, M, Duncan R, Aarts M, Clarke P, Wyllie DJ, Hardingham, GE “Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand” J Neuroscience 28: 10696-710 (2009)

Medine, CN, Rickman, C, Chamberlain, LH and Duncan RR “Munc18-1 prevents the formation of ectopic SNARE complexes in living cells” J Cell Sci 120: 4407-15 (2007)

Duncan RR, Bergmann A, Cousin MA, Apps DK, Shipston MJ “Multi-dimensional time-correlated single photon counting (TCSPC) fluorescence lifetime imaging microscopy (FLIM) to detect FRET in cells” J Microscopy 215: 1-12 (2004)

Duncan RR, Greaves, J, Wiegand, UK, Matskevich, I, Bodammer G, Apps DK, Shipston MJ, Chow RH “Functional and spatial segregation of secretory vesicle pools according to age” Nature 422: 176-80 (2003)

Outreach:

We are actively involved with public outreach activities: the Rickman group participate in annual schools outreach, extracting DNA from strawberries using household chemicals (sponsored by the Royal Society of Edinburgh). Members of the Duncan group regularly visit local schools, recently arriving with a lorry-load of Leica fluorescence microscopes to show kids the amazing things that can be seen inside cells!

We also ran a large exhibition at the ESRC ‘The revolution will be bio’ roadshow in November 2012. You can see more here.

Our images were recently displayed in the Wellcome Trust Gallery in Euston, as part of their ‘Truth and Beauty’ exhibition, showcasing art and science together. These images were also used to decorate the Wellcome Trust building on Euston Road, London.

We publish in high impact general interest journals, collaborate widely with a range of international researchers across disciplines and participate enthusiastically in public engagement activities.

Journal Cover art:

Images and data copyright LSI Laboratory

The LSI Laboratory is featured in the Nexxus Newsletter. Nexxus is a network organisation for the Life Science community in Scotland. The full Newsletter can be found here.

A poster presented in September 2011 to the Scottish Scientific Advisory Council (right) can be viewed here.